Bio-optical Imaging and Tissue Optical Property Modeling
In modern biomedical research, optical technology has become a powerful tool for exploring the dynamic behavior of biological tissues and molecules due to its non-invasive, high-resolution, multifunctional and real-time characteristics. From molecules, cells to tissues and organs, optical technology provides precise and intuitive solutions to multi-scale biological problems, which not only promotes basic research, but is also widely used in disease diagnosis and treatment.
Fig.1 Scheme of ALP enzyme-activated nanoprobes for responsive NIR FL imaging and MR imaging. (Chu B, et al., 2023)
Our Services
- Simulation of Biological Optical Imaging Technology
Fluorescence microscope modeling: Provides imaging simulation based on optical paths, optical component characteristics, and sample optical behavior to optimize fluorescence microscope experimental conditions.
Photoacoustic imaging simulation: Simulates the interaction between light and sound waves in tissues to help researchers optimize photoacoustic imaging technology.
Multispectral imaging analysis: Supports modeling of propagation and scattering characteristics of light in different bands in biological samples for multispectral diagnosis and analysis.
- Modeling of Biological Tissue Optical Properties
Tissue optical parameter determination: Analyze optical parameters such as scattering coefficient, absorption coefficient, and anisotropy factor of biological tissues through modeling.
Light transmission simulation: Based on Monte Carlo method, radiation transfer equation (RTE) and other technologies, simulates the transmission behavior of light in biological tissues, which is suitable for biomedical imaging and treatment optimization.
Analysis of tissue spectral characteristics: Predicts the range and efficiency of different light sources (such as lasers and LEDs) in biological tissues for disease detection and treatment modeling.
- Optical Instrument Development Support
Assists researchers in designing simulation models of new optical microscopes or imaging systems.
Provides suggestions for optical path optimization to improve instrument performance.
Generate visual reports showing key results for light propagation, scattering, and absorption in your model.
Advantages
- Customized solutions: tailor modeling solutions to your experimental needs.
- Efficient communication and feedback: quickly respond to your questions and provide detailed technical support.
- Detailed results visualization: generate high-quality reports and 3D simulations to clearly display simulation results.
- Experienced team: Our team is composed of senior experts in the fields of optics and biology, familiar with the needs of multidisciplinary cross-disciplinary research.
Technical Support
We use the following high-precision modeling methods and tools to provide solid support for your research:
- Monte Carlo optical simulation: suitable for efficient modeling of optical transmission in complex tissues.
- Optical finite element method: used to accurately analyze the behavior of light in heterogeneous media.
- Commercial and open-source tools: support professional software such as COMSOL, MATLAB, Lumerical, and combine Python to customize and develop exclusive models.
Application Area
Cancer Photodynamic
Evaluate the interaction between light and tumor tissue to provide a basis for optimizing phototherapy.
Brain Functional Imaging
Modeling the application of near-infrared spectroscopy (fNIRS) technology in brain activity research.
Histopathology Research
Analyze the changes in the optical properties of tissues under different disease conditions.
Imaging Systems Development
Assist in the development of advanced instruments such as super-resolution microscopes and multispectral imagers.
Results Delivery
After completing the simulation work, CD Biomodeling will provide you with comprehensive and professional results delivery to ensure that your research needs are fully met. These deliverables cover everything from technical reports to visualization data, from model files to follow-up support, helping you to better understand the simulation results and efficiently apply them to scientific research.
Simulation Report
Detailed technical description
Experimental parameters and settings
Result analysis and discussion
Visual Data and Charts
2D and 3D visualization images
Dynamic simulation animation
Graphical presentation of imaging results
Interactive Model Files
Project files based on professional modeling software
Model geometry settings, parameter tables, solver configuration
Data Files
Raw output data: Simulated optical data files
Processed data: Data tables or chart files (such as Excel, CSV formats)
To help researchers use optical technology more efficiently, CD Biomodeling provides comprehensive bio-optical imaging and tissue optical property modeling services, covering the entire process from theoretical design to application optimization. Through advanced modeling methods and professional technical support, we help researchers make breakthroughs in scientific research. Whether you are exploring the optical properties of biological tissues, developing new optical imaging technologies, or applying optical principles to study life sciences, our services will provide you with tailor-made solutions to help you break through scientific research bottlenecks. If you would like to learn more about the service details or get technical support, please feel free to contact us.
Reference
- Chu B, et al. Fluorescence, ultrasonic and photoacoustic imaging for analysis and diagnosis of diseases. Chem Commun (Camb). 2023;59(17):2399-2412.
For Research Use Only!
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