Photobiology and Photodynamic Modeling
Photobiology and photodynamic are important branches at the intersection of life science and physics, studying the interaction between light and biological systems and their wide applications in medicine, agriculture and the environment. From photosynthesis to photodynamic therapy, research in this field has not only promoted the development of basic science, but also demonstrated great potential in disease treatment, new material development and other aspects.
Fig.1 Photochemical and photophysical mechanisms of antimicrobial photodynamic therapy (aPDT). (Dharmaratne P, et al., 2020)
Our Services
- Photobiological Interaction Modeling
Photosynthesis simulation:
Simulate the photosynthesis process of plants, algae, etc. under different light intensities, light qualities and environmental conditions.
Provide light energy utilization efficiency (LUE) and quantum yield analysis.
Light response and regulation:
Simulate the mechanism of light action on biological molecules (such as DNA, protein).
Study the role of light regulation in cell signaling pathways.
Light environment design:
Optimize the spectral distribution of artificial light sources to promote specific biological processes, such as plant growth or microbial metabolism.
- Photodynamic Therapy (PDT) Modeling
Photosensitizer behavior simulation:
Simulate the distribution, absorption and excitation dynamics of photosensitizers in tissues.
Provide photosensitizer selection and dose optimization suggestions.
Light-tissue interaction:
Based on the Monte Carlo method, simulate the transmission path of photons in tumor tissues.
Analyze the effects of light absorption and scattering on treatment efficiency.
Photooxidation effect modeling:
Study the mechanism of light-induced reactive oxygen species (ROS) production and its biological effects.
Provide predictions of reactive oxygen diffusion and tissue damage range.
- Photodynamic Process Optimization
Multi-scale modeling:
Construct multi-scale photodynamic models from molecular, cellular to tissue levels.
Parameter optimization and sensitivity analysis:
Systematic evaluation of the effects of light intensity, wavelength, photosensitizer concentration and other parameters on efficacy.
Treatment plan simulation:
Provide a visual display of personalized treatment plans to assist clinical decision-making.
Advantages
- Customized service: tailor modeling solutions according to your specific research goals.
- Multidisciplinary team: combine knowledge of optics, biology, chemistry and computational science to provide you with innovative solutions.
- Efficient communication and feedback: timely respond to your questions to ensure a smooth research process.
- Support for research results transformation: help transform scientific research results into practical technologies or application solutions.
Technical Support
We use advanced modeling tools and algorithms, including but not limited to:
- Monte Carlo light transport algorithm: simulates the propagation behavior of light in complex tissues.
- Chemical kinetic modeling: predicts the dynamic changes of photosensitizer and reactive oxygen species reaction.
- Spectral analysis and optimization tools: optimize light source design and spectral parameters.
In addition, we combine multiple high-performance computing platforms (such as MATLAB, Python, COMSOL) to achieve efficient simulation and flexible data processing.
Application Area
Medical Treatment
Optimization of auxiliary photodynamic therapy (PDT) and photothermal therapy.
Agricultural Science
Optimization of plant lighting conditions to improve yield and quality.
Environmental Protection
Efficiency evaluation and optimization of photocatalytic degradation of harmful substances.
Material Development
Design and verification of new photosensitizers and nanomaterials.
Results Delivery
CD Biomodeling not only focuses on the scientificity and accuracy of simulation results, but also on their practicality and scalability in actual research. Whether it is theoretical analysis or practical application, these results can provide strong support for your research, helping you to more efficiently verify hypotheses, optimize experimental design, and take an important step in the scientific research process. The following are the specific deliverables we provide:
Simulation Report
Technical background and modeling method
Experimental parameters and conditions
Result analysis and discussion
Visualization Results
2D and 3D images
Dynamic charts
Optical and kinetic curves
Data Files
Raw simulation data
Processed data table
Model Files
Interactive modeling files
Parameter configuration documents
Photobiology and Photodynamic Modeling is an important method to study the interaction between light and biological systems and their mechanism of action in life processes. It covers a wide range of applications from photobiological processes (such as photosynthesis and photosensitization) to photodynamic therapy (PDT), and is widely used in medical treatment, agricultural optimization, and environmental protection.
CD Biomodeling focuses on providing professional photobiology and photodynamic modeling services for academic researchers. We use advanced modeling technology and precise simulation methods to optimize experimental design, analyze optical processes, and promote the realization of innovative results, providing strong support for your scientific research. If you would like to learn more about the service details or get technical support, please feel free to contact us.
Reference
- Dharmaratne P, et al. Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review. Materials & Design. 2020:112341.
For Research Use Only!
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