Design and Optimization of Microfluidic Devices
Microfluidics has attracted much attention due to its wide applications in life sciences, medical diagnosis, drug screening, and chemical engineering. Designing efficient and precise microfluidic devices is essential for optimizing liquid handling processes, improving experimental efficiency, and saving sample costs. However, the design of microfluidic devices faces many challenges, such as uneven fluid distribution, channel blockage, and high shear force. These problems need to be accurately predicted and optimized in the design stage to avoid high time and cost consumption in later experimental iterations.
Fig.1 Proposed microfluidic gradient generator design. (Micheli S, et al., 2022)
Our Services
- Microfluidic Device Design
Flow channel layout optimization: Simulate the fluid behavior under different flow channel geometries and design flow channel structures with optimal flow velocity distribution and pressure loss.
Mixer design: Optimize the design of passive and active mixers to achieve efficient liquid mixing.
Valve and pump optimization: Analyze the performance of microfluidic pumps and valves to improve the accuracy and reliability of flow control.
- Microfluidic System Performance Analysis
Fluid distribution uniformity: Simulate the fluid distribution in multi-inlet or multi-outlet devices to ensure uniform transmission of samples or reagents.
Shear force analysis: Study cell damage or particle fragmentation under high shear conditions and optimize the design to protect sample integrity.
Particle transport simulation: Evaluate the flow and deposition behavior of particles in microchannels to assist in optimizing particle separation or capture devices.
- Thermal and Fluid Coupling Optimization
Thermal management design: Simulate the heat transfer and temperature distribution of microfluidic devices to ensure reaction efficiency and device stability.
Thermosensitive material compatibility: Evaluate the interaction between fluids and materials at different temperatures and optimize the selection of microfluidic chip materials.
- Multi-Physics Coupling Modeling
Electrodynamic and magnetofluidics simulation: Simulate the behavior of fluids under the action of electric and magnetic fields to improve the efficiency of electrophoretic separation or magnetic particle capture.
Acoustic wave fluid control design: Use the acoustic microfluidic effect to optimize the structure and parameters of acoustic wave mixing and acoustic wave separation devices.
Advantages
Advanced simulation tools
Use leading simulation platforms such as ANSYS Fluent and COMSOL Multiphysics to ensure the accuracy and reliability of results.
Multidisciplinary support
Combine fluid mechanics, material science and electromagnetics to provide comprehensive solutions for complex microfluidic problems.
Results Delivery
To help customers understand the value of simulation analysis more intuitively, we will present the results through clear documents and dynamic visual models. Each delivery has been carefully organized to ensure that it can't only meet the in-depth technical needs, but also provide a reliable basis for decision-making and subsequent implementation. The following are the specific deliverables we provide:
- Detailed Design Report: Contain flow channel design solutions, optimization suggestions and performance analysis data.
- Dynamic Simulation Model: Dynamically display fluid flow rate, pressure and particle behavior through 3D visualization.
- Equipment Optimization Program: Provide complete design improvement suggestions and experimental verification support based on actual needs.
- Technical Support: Provide detailed explanation of simulation results and assists in subsequent equipment development and testing.
At CD Biomodeling, microfluidic modeling and simulation services, based on advanced computational fluid dynamics (CFD) technology and multi-physics coupling analysis, help customers achieve precise design and performance optimization of microfluidic devices, and accelerate product development and market applications. Our microfluidic modeling and simulation services are committed to combining innovation and efficiency to help you design microfluidic devices with excellent performance. If you would like to learn more about the service details or get technical support, please feel free to contact us.
Reference
- Micheli S, et al. Modeling-based design specifications for microfluidic gradients generators for biomedical applications. Biochemical Engineering Journal. 2022;181: 108415.
For Research Use Only!
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