Manipulation and Analysis of Biomolecules and Cells
Single-cell level research and biomolecule manipulation are key technical directions in the fields of modern life sciences and precision medicine. Compared with traditional population average analysis, single-cell analysis can reveal the heterogeneity between different cells and help scientists understand the complexity of biological systems more accurately. Biomolecular manipulation technology can achieve precise intervention in cell and molecular activities and is an important means to develop new diagnostic tools and treatment methods.
Fig.1 Schematic representation of hepatocyte growth in microfluidic devices modeled and investigated using computational fluid dynamics tools. (Bakuova N, et al., 2023)
Our Services
- Single-Cell Capture and Analysis
Provide efficient single-cell capture technology based on microfluidic chips.
Achieve real-time analysis at the single-cell level, such as gene expression, metabolite detection, etc.
Simulate and optimize capture efficiency and cell activity.
- Single-Cell Manipulation
Accurate cell sorting, manipulation and transport through microfluidic technology.
Apply to the separation and enrichment of rare cells (such as cancer stem cells).
High-throughput dynamic study of single-cell behavior and function.
- Biological Molecule Detection
Detection of biomolecules at the single molecule level, such as DNA, RNA, and proteins.
Provide high-sensitivity sensor integration solutions on microfluidic platforms.
Support multi-channel parallel analysis to improve experimental efficiency.
- Biological Modeling and Simulation
Provide modeling of the internal environment of microfluidic chips, including fluid dynamics, chemical gradient formation, and electric field distribution.
Optimize experimental conditions for cell/molecule manipulation and reduce the number of experimental iterations.
Achieve transport kinetics simulation of particles or molecules in complex microenvironments.
Advantages
High throughput and high sensitivity
Through customized microfluidic design, efficient sample processing and accurate analysis are achieved.
Customized solutions
Design exclusive microfluidic chips and optimize parameters according to experimental requirements.
Multi-field support
Covers single cell and molecular analysis needs in the fields of tumor research, stem cell research, drug screening, etc.
Data-driven optimization
Combine simulation platform and data modeling to provide the best experimental solution.
Results Delivery
We understand that high-quality results and professional data presentation are the core of successful experiments and research. Therefore, at the end of the service, we will provide you with the following comprehensive and detailed deliverables to ensure that your research needs are met and support follow-up work.
- Experimental Report
Complete experimental record: Cover experimental design, operation process, key parameters and experimental conditions.
Summary of experimental results: Core findings and conclusions based on experimental data.
- Data Package
Raw data file: Provide complete raw data obtained from the experiment, supports multiple common file formats
Analysis results: Cleaned and processed data sets, including statistical analysis and graphical results.
Visual content: Intuitively present results in the form of charts, 3D modeling, etc.
- Modeling and Simulation Results
Microfluidic simulation data: Include simulation results such as fluid dynamics, particle/cell motion trajectory, etc.
Optimization suggestions: Provide suggestions for improving experimental conditions and designs.
Model files: Provide reusable model files (such as CFD files, COMSOL files).
- Technical Documents and Guidance
Experimental operation manual: Provide detailed operation guides and maintenance suggestions for the microfluidic chip or system used.
Data interpretation guide: Interpret data results, including definitions of key indicators and description of reference ranges.
CD Biomodeling is committed to combining cutting-edge microfluidics technology with biological modeling and simulation capabilities to help customers overcome technical challenges in experiments and research in the field of single-cell analysis and molecular manipulation. Through our services, you can get full support from experimental design to data analysis. Whether it is studying rare cell types, optimizing drug screening processes, or exploring the interaction between molecules and cells, we can provide you with customized and efficient solutions to help your scientific research and industrial innovation. If you would like to learn more about the service details or get technical support, please feel free to contact us.
Reference
- Bakuova N, et al. Design, Simulation, and Evaluation of Polymer-Based Microfluidic Devices via Computational Fluid Dynamics and Cell Culture "On-Chip". Biosensors. 2023; 13(7):754.
For Research Use Only!
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