Organ-on-a-chip and Biological Simulation
Organ-on-a-Chip is an emerging microfluidic technology that can simulate the complex functions and microenvironment of human organs and is an important tool in the fields of precision medicine, drug screening, toxicology research, etc. Through biological modeling and simulation, we can simulate fluid dynamics, molecular transport and cell behavior during the design and optimization of organ chips, providing theoretical support for efficient experimental plans.
Fig.1 Evaluate the fluid distribution in three parallel microchannels. (Pisapia F, et al., 2022)
Our Services
- Organ-on-a-Chip design and optimization modeling
Microfluidic channel design
Simulate the fluid dynamics behavior in the microfluidic channel, optimize the shear force, flow velocity distribution and pressure gradient.
Design and optimize the channel geometry to adapt to the physiological needs of the target cells or tissues.
Multi-physics field coupling modeling
Couple fluid mechanics, electric fields, heat transfer and chemical reaction kinetics to simulate the multiple action mechanisms of the organ chip.
Predict the impact of different parameters on chip performance (such as drug distribution, gas exchange).
- Dynamic biological process simulation
Cell behavior simulation
Simulate the adhesion, migration, proliferation and differentiation behavior of cells under fluid shear force and chemical gradient.
Optimize the cell arrangement and tissue morphology reconstruction scheme in the organ chip.
Molecular transport modeling
Simulate the diffusion, convection and mass transfer process of drug molecules, oxygen, nutrients, etc., in the chip.
Analyze the local concentration distribution of drugs in the chip microenvironment and optimize the experimental design.
- Organ function simulation and verification
Simulate key organ functions
Construct an in vitro liver metabolism model to study drug metabolism and toxic effects.
Simulate the gas exchange process in the alveoli for the study of respiratory diseases.
Build a blood-brain barrier model to analyze the brain penetration efficiency of drugs.
Multi-organ coupling system modeling
Simulate the interaction between multiple organ chips (such as liver-kidney drug metabolism cycle).
Analyze the changes in dynamic physiological indicators in the system to provide data support for personalized treatment.
- Experimental verification of simulation results
Experimental-simulation result comparison analysis
Compare the simulation results with the experimental data to verify the reliability and accuracy of the model.
Provide experimental optimization suggestions to shorten the R&D cycle.
Feedback optimization modeling
Continuously optimize the simulation model based on experimental feedback to improve prediction capabilities and research.
Advantages
Multi-level modeling capabilities
From the cell scale to the organ system, it fully covers the modeling needs of different biological levels to ensure the high accuracy and applicability of the simulation results.
Innovative design support
In-depth integration of the latest research in microfluidics and biomedicine to promote the breakthrough development of organ chip technology.
Experimental and simulation integration
Provide experimental-simulation integrated services to achieve rapid verification and optimization, reduce R&D costs and the risk of experimental failure.
Leading simulation tools
Use world-class simulation platforms such as COMSOL and ANSYS Fluent, combined with self-developed algorithms, to provide accurate modeling and simulation results.
Results Delivery
Choosing us means choosing efficiency, precision and professionalism. Our organ chip modeling and simulation services not only provide you with detailed deliverables, but also help you achieve breakthroughs in research and development through strong technical support and optimization solutions.
- Modeling Report
Includes microfluidic design parameters, simulation model structure and detailed modeling process.
Key assumptions and parameter descriptions used in the simulation.
- Simulation Results and Analysis
Visualization charts of simulation results such as drug diffusion, cell behavior, and fluid distribution.
Suggestions for experimental optimization and model improvement solutions
- Model Files
Provide complete simulation model files (such as COMSOL files) to support subsequent modifications and secondary applications.
- Technical Documentation and Support
Detailed operation manuals and model application guides.
Provide consultation and problem solving to ensure the smooth implementation of the model in practical applications.
Organ-on-a-chip and biomimetic technologies are ushering in a new era of scientific research and innovation. Whether you are exploring basic biological mechanisms or accelerating drug development, we will provide you with reliable modeling and simulation support to help your research stay at the forefront. If you would like to learn more about the service details or get technical support, please feel free to contact us.
Reference
- Pisapia F, et al. Organ-on-a-Chip: Design and Simulation of Various Microfluidic Channel Geometries for the Influence of Fluid Dynamic Parameters. Applied Sciences. 2022; 12(8):3829.
For Research Use Only!
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