Drug Delivery and Targeted Therapy
In modern medical research, drug delivery and targeted therapy technologies are gradually becoming key solutions for disease treatment, especially in the fields of cancer and neurodegenerative diseases. Through biological modeling and simulation of microfluidic platforms, we can simulate the dynamic behavior of drugs in microscale environments, optimize delivery pathways, and improve targeting efficiency, thereby promoting drug development into the era of precise and personalized treatment.
Fig.1 Microfluidic platforms for generation of self-assembled drug and gene carriers. (Damiati S, et al., 2018)
Our Services
- Drug Carrier Transport Modeling
Simulate the transport behavior of different drug carriers (such as liposomes, nanoparticles, microspheres, etc.) in a microfluidic environment.
Analyze the diffusion, deposition, adhesion and membrane penetration of carriers in fluids.
Optimize the physical properties of carriers (such as particle size, surface charge) to improve targeting efficiency.
- Microfluidic Drug Delivery System Design
Simulate the distribution and flow rate control of drugs in complex microfluidic networks.
Optimize drug dosage regulation and release rate to improve therapeutic effects and reduce side effects.
Study the interaction between drugs and biological samples (such as cells and tissues) in multi-channel systems.
- Targeted Therapy Optimization
Model and analyze the enrichment efficiency of drugs at the target site, and evaluate the bioavailability and toxicity distribution of drugs.
Simulate the penetration ability and residence time of drug carriers in the tumor microenvironment.
Optimize the design of carrier surface modification (such as antibodies, peptide chains) to improve targeting.
- Multi-physics Field Coupling Simulation
Simulate the regulatory effects of electric fields, magnetic fields, ultrasound, etc. on drug transport behavior (such as targeted delivery of magnetic nanoparticles).
Study the response mechanism of thermosensitive and pH-sensitive carriers in complex in vivo environments.
- Microfluidic Organ Chip Modeling
Reconstruct disease models (such as tumors and blood-brain barriers) in microfluidic chips for drug transport research.
Simulate the dynamic distribution of drugs in in vitro organ chips to provide consistency verification between in vitro and in vivo.
Advantages
Multi-dimensional simulation support
Provide multi-level modeling services from macroscopic fluid transport to molecular-scale interactions, and comprehensively analyze the key parameters in the drug delivery process.
Deep integration of experiments and simulations
Achieve bidirectional verification of simulation results and experimental data to ensure the accuracy and applicability of the model.
Personalized solutions
Customize the design for different research goals to optimize drug carrier performance and treatment options.
Advanced tool support
Use advanced simulation platforms such as COMSOL and ANSYS Fluent, combined with self-developed biological modeling algorithms, to provide high-precision simulation results.
Results Delivery
CD Biomodeling understands that high-quality results and professional data presentation are the core of successful experiments and research. Therefore, at the end of the service, we will provide you with the following comprehensive and detailed deliverables to ensure that your research needs are met and support follow-up work.
- Data Package
Original simulation data and cleaned data analysis results.
Visual content (such as flow field distribution map, drug concentration heat map).
- Model File
Provide reusable CFD model or multi-physics simulation file.
- Simulation Report
Detailed analysis of drug transport pathways.
Quantitative evaluation results of targeted therapy efficiency.
Carrier design optimization suggestions.
- Technical Document
Simulation parameters, conditions and results.
Technical diagrams that can be used for scientific research publications.
At CD Biomodeling, we combine advanced microfluidic design and multi-physics modeling technology to provide comprehensive design optimization and data support for drug delivery systems and targeted therapy solutions. Whether it is the fluid dynamics analysis of particle carriers or the drug release behavior in complex microenvironments, we can provide you with customized solutions to facilitate scientific research and clinical transformation. If you would like to learn more about the service details or get technical support, please feel free to contact us.
Reference
- Damiati S, et al. Microfluidic Devices for Drug Delivery Systems and Drug Screening. Genes. 2018; 9(2):103.
For Research Use Only!
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